9:39 AM 8/25/2020 - Kremlin: Navalny poisoning accusations 'empty noise'



9:39 AM 8/25/2020 - Kremlin: Navalny poisoning accusations 'empty noise'

The Brooklyn News And Times
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The Brooklyn News And Times 
6:48 AM 8/25/2020 - New Wave of COVID-19 Cases Hits Brooklyn Communities
Tue, 25 Aug 2020 10:51:00 +0000
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Saved Stories - 1. New York and Brooklyn
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Saved Stories - 1. New York and Brooklyn 
Kremlin: Navalny poisoning accusations 'empty noise'

The Kremlin has rejected accusations of involvement in an alleged attack on Russian opposition leader Alexei Navalny who is in a coma in a German hospital.

Fierce storm surge feared as Laura bears down on Gulf Coast

Tropical Storm Laura has entered the warm waters of the Gulf of Mexico, gathering strength on a path to hit the U.S. coastline early Thursday as a major hurricane, capable of devastating damage.

Nationwide manhunt for suspects in three-state shooting spree ends with arrests of man, woman

A nationwide manhunt for the suspects involved in a series of shootings spanning three states has culminated in two arrests.





Brooklyns most and least expensive neighborhoods - The Real Deal

Brooklyns most and least expensive neighborhoods  The Real Deal
Crash on Brooklyn-bound Verrazzano-Narrows Bridge causes delays - SILive.com

Crash on Brooklyn-bound Verrazzano-Narrows Bridge causes delays  SILive.com
The Brooklyn News And Times - bklynnews.com bklynnews.com

The Brooklyn News And Times - bklynnews.com bklynnews.com

AP-NORC poll: Many in US shoring up finances amid downturn

A new poll from The Associated Press-NORC Center for Public Affairs Research finds 45% of Americans say they are setting aside more money than usual during the coronavirus pandemic.


Laura, now a hurricane, takes aim at U.S. Gulf Coast

Laura has become a hurricane shortly after moving over the warm waters of the Gulf of Mexico.


Japanese Prime Minister Shinzo Abe sparks health concerns with hospital visit as he becomes nations longest-serving leader

A second hospital visit in the span of a week has sparked concern for the health of Japanese Prime Minister Shinzo Abe, who just set the record for the countrys longest serving head of government.



Florida appeals judges ruling that blocks state order to reopen schools amid coronavirus pandemic

Florida officials have already filed an appeal against a judges Monday ruling that schools could not be forced to reopen for in-person learning, continuing a contentious battle between administrators and teachers.



Father says Black Wisconsin man shot by police is paralyzed

The father of a Black man who was shot, apparently in the back, by police in Kenosha, Wisconsin, says his son was left paralyzed from the waist down.


Reimagined Coney Island Mermaid Parade slated for this weekend

Sea monsters and fin folk can tune into a virtual livestream of Coney Island’s beloved Mermaid Parade this Saturday, Aug. 29, which will feature musical performances, dances, and marches, according to its organizers.
“You might see some familiar faces,” said Mark Alhadeff, a member of the arts organization Coney Island USA who helped host the event, now in its 38th year. “A lot of your favorites from the Mermaid Parade sent things in.”
The Mermaid Parade, which was postponed from its original June 20 date due to the coronavirus outbreak, will be held online to prevent the virus from spreading, Alhadeff said. A small group of participants will perform in an undisclosed, Coney Island location for a livestream that viewers can stream on Coney Island USA’s website, he said.
“Our MCs are here, some specials guests are here,” said Alhadeff, who emphasized that the in-person performance space will follow strict social-distancing guidelines. “It’s a very, very big space. It’s incredibly well ventilated.”
In addition to live dances and marches, the event will also feature pre-recorded performances by well-known musicians singing songs about Coney Island, such as Arlo Guthrie, the lead singer of the rock band Death Cab for Cutie, and the lead singer of the alternative rock band The Feelies.

Ben Gibbard, the lead singer for the hit rock band Death Cab for Cutie, submitted a video of him singing a song about Coney Island.Ben Gibbard
The show has received nearly 200 video submissions from potential participants so far, said Alhadeff, who added that some of his favorite footage features costumed revelers parading through their apartments by themselves.
“We’re hoping to have some people who literally parade,” he said. “People going back and forth across their apartments it makes me happy.”
The event’s hosts originally planned to partner with bars across the country to host disparate, live-streamed celebrations of the festival, but Coney Island USA decided to go completely virtual out of concern for viewers’ health, Alhadeff said.
“Because of what’s going on in the world, we killed the venue concept on the whole,” he said. “We are not officially sanctioning any venues.”

Parade organizers with Coney Island USA are working tirelessly to set up the venue where some performers will perform live for the virtual Mermaid Parade on Aug. 29.Norman Blake
Rather than taking the form of a parade or party, the reimagined event will imitate a 1970s charitable telethon, Alhadeff said. Viewers can make donations throughout the livestream on the organization’s website, which will go to Coney Island USA and other local non-profits including include the youth services program Salt and Sea Mission, the southern Brooklyn community organization Urban Neighborhood Services, and the Brooklyn arts organization BRIC, among others.
In the style of a telethon, the event’s hosts will give shoutouts and prizes to donors, impersonate the 1970s telethon performer Jerry Lewis, and count the donations as they roll in on a gigantic thermometer, Alhadeff said.
Participants may also enter the parade’s annual costume awards, known as the Mermies, which dole out trophies for the best mermaid and Neptune costumes, the best kids costume, the best sea creature, and the best music group, among other categories.
Despite the parade’s setbacks due to the coronavirus outbreak, Alhadeff said that the Aug. 29 event will capture the spirit of the fun-loving parade.
“It’s basically a big variety show with Jerry [Lewis] in between,” he said. “If you’ve been to the Mermaid Parade, it will probably feel familiar.”



Kremlin: Navalny poisoning accusations 'empty noise'

Michael_Novakhov shared this story from News 12 - Home.

The Kremlin has rejected accusations of involvement in an alleged attack on Russian opposition leader Alexei Navalny who is in a coma in a German hospital.


Kenosha delayed body cameras for years before Blake shooting

Officials in Kenosha, Wisconsin, have put off implementing body cameras for police officers, even though leaders unanimously endorsed them more than three years ago as a way to increase police accountability and collect evidence at scenes of domestic violence.


6:48 AM 8/25/2020 - New Wave of COVID-19 Cases Hits Brooklyn Communities



6:48 AM 8/25/2020 - New Wave of COVID-19 Cases Hits Brooklyn Communities




Michael Novakhov - SharedNewsLinks℠ | In Brief | 
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Michael Novakhov - SharedNewsLinks 
Kenosha delayed body cameras for years before Blake shooting
The Latest: UN says tourism impact of pandemic devastating
Trump convention blurs official business and politics
WHAT TO WATCH: Melania, Pompeo and Trump at GOP convention
Republican convention showcases rising stars, dark warnings
Scotland's handling of virus boosts support for independence
Germany economy's 2nd-quarter decline revised to below 10%
Global stocks rise, spurred by hopes for COVID treatment
Police use tear gas as protesters loot and burn buildings in Kenosha after Jacob Blakes shooting - Washington Post
New Wave of COVID-19 Cases Hits Brooklyn Communities
New Wave of COVID-19 Cases Hits Brooklyn Communities
NPR News: 08-25-2020 6AM ET
RT @thehill: Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW
5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo
5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov
RT @thehill: Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l
Google Alert - Covid-19: Governor Cuomo Announces New Record-Low COVID-19 Test Positivity Rate
The origins and evolution of the SARS-CoV-2 virus
11:49 AM 8/24/2020 - Portland police forced to prioritize protests unable to immediately respond to other 911 calls
Freedom FM Radio Network: FOX News: Portland police forced to prioritize protests unable to immediately respond to other 911 calls
New York Daily News: 13 killed in stampede after trying to run from cops at illegal nightclub party in Peru: officials
Top stories Google News: Disability, Work and Coronavirus: What Happens Now? The New York Times
7:40 AM 8/24/2020 - Saved, Shared Stories, Tweets
Steve Bannons indictment marks the end of a political era - Tweets by @mikenov Sat, 22 Aug 2020 06:40:37
6:07 AM 8/24/2020 - Report: Israel pushed NSO spyware to Gulf states to help track dissidents. Government reported to mediate deals worth hundreds of millions with Bahrain, Oman, Saudi Arabia, UAE
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Michael Novakhov - SharedNewsLinks 
Kenosha delayed body cameras for years before Blake shooting

Michael_Novakhov shared this story from News 12 - Home.

Officials in Kenosha, Wisconsin, have put off implementing body cameras for police officers, even though leaders unanimously endorsed them more than three years ago as a way to increase police accountability and collect evidence at scenes of domestic violence.

The Latest: UN says tourism impact of pandemic devastating

Michael_Novakhov shared this story from News 12 - Home.

The United Nations chief says the tourist industry has been devastated by the COVID-19 pandemic, with $320 billion lost in exports in the first five months of the year and over 120 million jobs at risk.

Trump convention blurs official business and politics

Michael_Novakhov shared this story from News 12 - Home.

Plenty of presidents have walked right up to the line separating official business from politics or even stepped over it.

WHAT TO WATCH: Melania, Pompeo and Trump at GOP convention

Michael_Novakhov shared this story from News 12 - Home.

Tuesdays program at the Republican National Convention is likely to wade into familiar waters, with a lineup expected to speak on divisive issues like abortion and cancel culture, while lambasting Democratic rival Joe Biden and the Democrats' progressive wing.

Republican convention showcases rising stars, dark warnings

Michael_Novakhov shared this story from News 12 - Home.

Republicans opened Monday nights prime-time convention with dark warnings about Americas future if President Donald Trump doesnt win a second term.

Scotland's handling of virus boosts support for independence

Michael_Novakhov shared this story from News 12 - Home.

Scottish leader Nicola Sturgeon has won praise for her handling of the coronavirus pandemic, her calm and sober response to the crisis standing in contrast to the sometimes-chaotic approach of U.K. Prime Minister Boris Johnson.

Germany economy's 2nd-quarter decline revised to below 10%

Michael_Novakhov shared this story from News 12 - Home.

Germany's official statistics agency says the country's economy, Europes biggest, shrank slightly less in the second quarter than originally estimated.

Global stocks rise, spurred by hopes for COVID treatment

Michael_Novakhov shared this story from News 12 - Home.

Asian shares are mostly higher as investors hang onto hopes the coronavirus pandemic may come under control with treatments being developed.

Police use tear gas as protesters loot and burn buildings in Kenosha after Jacob Blakes shooting - Washington Post

Michael_Novakhov shared this story from "Madison Brooklyn" - Google News.

Police use tear gas as protesters loot and burn buildings in Kenosha after Jacob Blakes shooting  Washington Post
New Wave of COVID-19 Cases Hits Brooklyn Communities

Michael_Novakhov shared this story from Google Alert - Coronavirus in brooklyn.

While the Boro Park Jewish community was hit hard early on by the coronavirus, and it seemed that the disease then seemed to have nearly ...
New Wave of COVID-19 Cases Hits Brooklyn Communities

Michael_Novakhov shared this story from Hamodia.

NEW YORK -
While the Boro Park Jewish community was hit hard early on by the coronavirus, and it seemed that the disease then seemed to have nearly disappeared, in recent days it turns out that there are dozens of cases of patients who became infected with the virus again. Hundreds of people were niftar in March and April. Currently, there are a few patients in the hospital and even some in the ICU.
On Monday researchers in Hong Kong reported that a man there had been reinfected with the coronavirus four and a half months after being declared recovered.
But a true reinfection requires genetic testing of the virus in both the first and second infection to see whether the two instances of the virus differ slightly.
The gabbaim of the Bobov kehillah in Boro Park on Monday issued a warning that new cases of coronavirus are cropping up.
They said that people at risk should be careful not to be in places where social distancing is not possible. At risk is defined as anyone over the age 60, if he or she has underlying conditions, or doesnt have antibodies.
Williamsburg Hatzolah told their members that they have also received reports that some people in the community have tested positive for coronavirus. They noted that they are monitoring the situation closely.
We ask all members to make sure to wear PPE on every single call for the safety of the members and the safety of our community, they request, and whenever you are dispatched to a suspected Covid call or a confirmed Covid call to contact W-80 so we can keep track and take the appropriate steps.
NPR News: 08-25-2020 6AM ET

Michael_Novakhov shared this story from NPR News Now.

NPR News: 08-25-2020 6AM ET



Download audio: https://play.podtrac.com/npr-500005/edge1.pod.npr.org/anon.npr-mp3/npr/newscasts/2020/08/25/newscast060746.mp3?awCollectionId=500005&awEpisodeId=905763932&orgId=1&d=300&p=500005&story=905763932&t=podcast&e=905763932&size=4500000&ft=pod&f=500005
RT @thehill: Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW

Michael_Novakhov shared this story from mikenov on Twitter.

Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW



Retweeted by mikenov on Tuesday, August 25th, 2020 9:39am


164 likes, 60 retweets
5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo

Michael_Novakhov shared this story from mikenov on Twitter.

5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo



5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov

Michael_Novakhov shared this story from The FBI News Review.

New Wave of COVID-19 Cases Hits Brooklyn Communities

While the Boro Park Jewish community was hit hard early on by the coronavirus, and it seemed that the disease then seemed to have nearly ...
German FM heads to Greece, Turkey as regional tension mounts

Germany's foreign minister is heading to Greece and Turkey Tuesday in an effort to ease increasing tension between the two neighbors that are at loggerheads over prospecting rights in the eastern Mediterranean.






RT @thehill: Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW

Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW



Retweeted by mikenov on Tuesday, August 25th, 2020 9:39am


164 likes, 60 retweets
5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo

5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo



5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov

 


5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov




Michael Novakhov - SharedNewsLinks℠ | In Brief | 
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Michael Novakhov - SharedNewsLinks 
RT @thehill: Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l
Google Alert - Covid-19: Governor Cuomo Announces New Record-Low COVID-19 Test Positivity Rate
The origins and evolution of the SARS-CoV-2 virus
11:49 AM 8/24/2020 - Portland police forced to prioritize protests unable to immediately respond to other 911 calls
Freedom FM Radio Network: FOX News: Portland police forced to prioritize protests unable to immediately respond to other 911 calls
New York Daily News: 13 killed in stampede after trying to run from cops at illegal nightclub party in Peru: officials
Top stories Google News: Disability, Work and Coronavirus: What Happens Now? The New York Times
7:40 AM 8/24/2020 - Saved, Shared Stories, Tweets
Steve Bannons indictment marks the end of a political era - Tweets by @mikenov Sat, 22 Aug 2020 06:40:37
6:07 AM 8/24/2020 - Report: Israel pushed NSO spyware to Gulf states to help track dissidents. Government reported to mediate deals worth hundreds of millions with Bahrain, Oman, Saudi Arabia, UAE
7:04 AM 8/24/2020 - Tweets by @mikenov: News - NSO Group and FBI
mikenov on Twitter: RT @haaretzcom: Trump and Netanyahu are using textbook gaslighting tactics. But there are ways to resist their psychological manipulation h
1. World from Michael_Novakhov (27 sites): FOX News: AI pilot beats human in clean sweep of virtual F-16 dogfights, human fails to register a single hit
2:14 PM 8/23/2020 - WATCH: Graham shares newly declassified FBI docs showing 'clear' bias toward Trump - Michael Novakhov - SharedNewsLinks
Trump News TV from Michael_Novakhov (15 sites): FoxNewsChannel's YouTube Videos: WATCH: Graham shares newly declassified FBI docs showing 'clear' bias toward Trump
"fbi and trump" - Google News: Transcript: Former FBI Director James Comey on "Face the Nation," August 23, 2020 - CBS News
"fbi criticism" - Google News: Comey: Bannon in 'a world of trouble' | TheHill - The Hill
Trump News TV from Michael_Novakhov (15 sites): CNN's YouTube Videos: Covid-19 case counts trending up in 9 states
mikenov on Twitter: 11:47 AM 8/23/2020 - "A liar with 'no principles'" trumpinvestigations.blogspot.com/2020/08/1147-a pic.twitter.com/0rhaBiwoB1
"house judiciary committee" - Google News: How a Senate panel went beyond Mueller in documenting Trump campaign contacts with Russia - KTEN
Trump News TV from Michael_Novakhov (15 sites): CNN's YouTube Videos: Trump's sister criticizes her brother in secretly recorded audio
Top stories - Google News: Coronavirus hasn't stopped groups from gathering, but it has led to grim consequences - CNN
The National Interest: The Classic Remington Model 1100 Shotgun: All-Around Excellence Through the Decades
Stars and Stripes: High winds could fan already-enormous California wildfires
"Russia" - Google News: How a Senate panel went beyond Mueller in documenting Trump campaign contacts with Russia - CNN
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Michael Novakhov - SharedNewsLinks 
RT @thehill: Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l

Michael_Novakhov shared this story from mikenov on Twitter.

Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l



Retweeted by mikenov on Tuesday, August 25th, 2020 9:14am


162 likes, 48 retweets
Google Alert - Covid-19: Governor Cuomo Announces New Record-Low COVID-19 Test Positivity Rate

Michael_Novakhov shared this story from Disease X-19 General Issues from Michael_Novakhov (4 sites).

17th Straight Day with Positivity Rate Below 1 Percent; 0.66 Percent of Yesterday's COVID-19 Tests were Positive. Port Authority of New York and New ...

 Google Alert - Covid-19
The origins and evolution of the SARS-CoV-2 virus

Michael_Novakhov shared this story from World Socialist Web Site (en).

 

The origins and evolution of the SARS-CoV-2 virus

By Frank Gaglioti
24 August 2020
The SARS-CoV-2 virus that causes the disease COVID-19 is nimbly and stealthily racing through community after community devastating the worlds population. Over 23 million people have contracted the virus worldwide and 810,000 have died. It is critical to review the evolutionary history of this particular virus to provide necessary insights into how the pandemic can be brought under control.
Researchers worldwide are working arduously to trace the virus globally by studying samples obtained from various nations looking for subtle mutations that it undergoes as it infects, replicates and multiplies, providing them clues to the source and route of spread.
COVID-19 is caused by a type of coronavirus known as SARS-CoV-2, named for its similarity to the coronavirus that caused SARS. The virus is called a coronavirus because it is covered by club-like structures that give the virus a similar look to the suns corona in electron micrographs.
The SARS-CoV-2 virus is part of a family of organisms that are known to infect mammals and birds. The Coronaviridae family are made up of a positive-sense single-stranded RNA completely enveloped in a complex protein and bilipid shell. These viruses are relatively large, consisting of 26 to 32 kilobase pairs. RNA or ribonucleic acid is a nucleic acid that is essential for all reproductive processes and like DNA.
The first known scientific encounter with this family of virus is thought to be when veterinarians puzzled over bronchial infections afflicting cats, pigs, and chickens in the early 20th century.
Study of disease afflicting and damaging tobacco crops in the late 19th century led some thoughtful scientists like Dimitri Ivanovsky to conjecture the existence of non-bacterial infectious agents causing the tobacco mosaic disease. It would take another 50 years to capture the first images of the Tobacco Mosaic Virus. The invention of the electron microscope in 1931 enabled scientists to observe viruses more closely, allowing a more extensive and direct study of these micro-organisms. Virology as a field began to flourish.
Human coronaviruses were first identified in the 1960s. Seven species of coronavirus are known to afflict humans. Four result in relatively mild upper respiratory tract conditions, including the virus 229E that causes the common cold, along with NL63, OC43 and HKU1.
The other three strains, SARS, MERS, and SARS-CoV-2, are far more virulent. All these viruses were new to human populations when they first arose in the 21st century. A feature of SARS, MERS and COVID-19 is that they had a zoonotic origin, that is they originated in animal populations and then jumped into humans. The SARS outbreak in 2002, with a case fatality rate of 11 percent, showed the world the deadly potential of coronaviruses, but this was a warning that was mostly ignored. There had only been 8,422 cases and since 2004 no SARS-CoV has been reported worldwide. One advantage for public health responses to SARS was that it had an incubation period of 4 to 6 days and patients presented with symptoms prior to becoming infectious.
In their extensive investigations, the World Health Organisation (WHO) concluded that the SARS virus originated in bat populations, but the exact species remains unknown. Work commenced on the development of a SARS vaccine with testing on animals. The vaccine resulted in protective immunity but produced an immune mediated hypersensitivity as an adverse effect. The SARS threat, for unknown reasons, expired after six months though limited outbreaks did occur later.
With the threat of a pandemic having ended after six months, so did any interest in funding a vaccine, as pharmaceutical companies saw no profit in funding or exploring such research. The co-director of the Center for Vaccine Development at Texas Childrens Hospital and dean of the National School of Tropical Medicine at the Baylor College of Medicine in Houston, Dr. Peter Hotez, had been attempting to develop a SARS vaccine in 2016 but couldnt get funding for his work. We tried like heck to see if we could get investors or grants to move this into the clinic ... But we just could not generate much interest, he said.
We could have had this ready to go and been testing the vaccines efficacy at the start of this new outbreak in China (COVID-19) There is a problem with the ecosystem in vaccine development, and weve got to fix this, Hotez said.
The genomic sequence of the SARS virus was published in August 2003 by Chinese scientists in Beijing. In actuality, when the cause of the pneumonia-like illness was first identified in Wuhan, some believed this was a new outbreak of the SARS virus. SARS-CoV-2 and SARS share a genomic sequence that is approximately an 80 percent match.
Middle East Respiratory Syndrome, or MERS, emerged in Saudi Arabia in 2012 and had a zoonotic origin in bats and was spread to humans through contact with dromedary camels. The virus produced symptoms similar to SARS but it had a low infectivity though highly lethal. Of the reported 2,500 cases, 35 percent died from the disease.
With limited capacity to spread from human to human, it was mainly passed through contact with infected people in hospitals. In the main it was concentrated in the Arabian Peninsula, although there were further outbreaks in South Korea in 2015 and Saudi Arabia in 2018. It continues to smoulder in the Middle East.
When the SARS CoV-2 virus emerged in late 2019, the world was totally unprepared. Health systems internationally had been systematically run down and were ill-equipped to respond. The warnings from WHO of the dangerous potential of the virus were largely ignored or belittled. The murderous government policies that dominated have been described as malign neglect or herd immunity.
SARS CoV-2 arose in Wuhan in December 2019. The virus is thought to have originated from bats and to have transferred to humans through an intermediary species. The exact origins of the virus may never be known. It is quite possible we wont find it (the species). In fact, it would be exceptionally lucky if we land on something, a geneticist from University College London, Lucy van Dorp, told Nature .
Back in 2013, the Wuhan Institute of Virology had investigated the coronavirus genome from the horseshoe bat ( Rhinolophus affinis ). The viruses named RATG13 and SARS-CoV-2 were found to be 96 percent genetically similar. There are, however, subtle molecular changes that continue to be investigated that contribute to selection pressures that drive the virulence, pathogenicity, and immunogenic qualities of the virus.
In their detailed analysis of the origin of the SARS-CoV-2 virus, Andersen et al., 2020, offered three possible explanations: 1) natural selection in an animal host before jumping into humans, 2) natural selection in humans after the virus transferred into human hosts, and 3) the product of artificial manipulation, which has been refuted by several virologists. According to Van Dorp, the 4% difference between the genomes of SARS-CoV-2 and RATG13 still represents some 50 years since they last shared a common ancestor.
It was thought that pangolins ( Manis javanica ), a scaly ant-eating mammal, may be the intermediate host between bats and humans, but genetic studies indicate that as unlikely. However, some scientists think that because coronavirus-like SARS-CoV-2 cases have been found in pangolins, that species cannot be ruled out as the intermediary source.
Scientists are currently examining species of animals that were kept and sold in the live markets in Wuhan where bats may have been in the buildings roof near animals and humans. Presently a team of experts from the WHO are working with their Chinese counterparts to answer this pressing question.
The opportunities for these viruses to spill over across a very active wildlife-livestock-human interface is clear and obvious, the president of the EcoHealth Alliance in New York City, Peter Daszak, told Nature. The complex evolutionary history of SARS-CoV-2 disproves President Donald Trumps ignorant claims (which have a political purpose) that the virus came out of a Chinese laboratory. Whether they [China] made a mistake, or whether it started off as a mistake and then they made another one, or did somebody do something on purpose? Trump said.
In a recent paper published in Nature Microbiology Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the covid-19 pandemic, led by Maciej F Boni from the Center for Infectious Disease Dynamics at Pennsylvania State Universityfound that the lineage of SARS-CoV-2 had been circulating in bat populations for decades. If these viruses have been around for decades that means that theyve had lots of opportunity to find new host species, including humans, said Professor David Robertson from the University of Glasgow.
Scientists have carefully examined the Receptor Binding Domain (RBD) of the genetic sequence that codes for the spike protein, the necessary structure on the virus exterior shell that is used to bind and penetrate the human cell. The spike protein has been compared to a grappling hook that grips the host cell, then creates a cleavage site that enables the opening and penetration into the host cell.
This means that the SARS-CoV-2 spike proteins had evolved to target a feature of human cells known as angiotensin converting enzyme 2 receptor (ACE2) which are well known to assist in regulating blood pressure.
Andersen et al ., remark that the RBD is the critical component of the spike protein that allows it to bind to ACE2 receptors. SARS-CoV-2 appears to bind with great affinity to the human ACE2 receptors, but computational analysis predicted that the interaction is not ideal. According to the New York Times, the authors indicate that the high-affinity bindings of the virus spike protein to human ACE2 is most likely a by-product of natural selection that has permitted another optimal binding solution to arise. They then conclude that this is strong evidence that SARS-CoV-2 is not a product of genetic reconstruction or tampering.
These two features of the virus, the mutations in the RBD portion of the spike protein and its distinct backbone, rule out laboratory manipulation as a potential origin for SARS-CoV-2, wrote Kristian Andersen, associate professor of immunology and microbiology at Scripps Research, and co-leader of the study.
With SARS-CoV-2 virus proliferating around the world, the opportunity arises for further mutations and the emergence of new strains of the virus. This can mean that new virus strains may develop in the future not treatable by possible vaccines that were originally made to treat older strains.
According to Assistant Teaching Professor of Computer Science and Technology Niema Moshiri, COVID-19s mutation rate is lower than seasonal influenza. The SARS-CoV-2 genome has a limited repair function that edits out most mutations. This has meant the virus has remained relatively uniform.
What we are finding is that the SARS-CoV-2 virus appears to be mutating more slowly than the seasonal flu which may allow scientists to develop a vaccine, Moshiri wrote on LiveScience. Despite this, variations do occur, and virologists are constantly looking at the variants to determine if a more virulent strain may be emerging or if the virus is losing its potency.
Scientists are collecting virus sequences and storing them in a globally available database. This is used to determine the rate of mutation and where in the virus genome mutations are occurring. Such mutations can affect the virulence and how effectively the virus can infect human host cells. The existence of different viral strains can be used to trace outbreaks.
Analysis of the SARS-CoV-2 virus from different countries has shown that the virus has undergone several predicted but insignificant mutations already. Scientists led by Peter Forster, along with researchers based in the UK and Germany, traced 160 COVID-19 genomes from China, Europe, and the US. They identified three strains of the virus called A, B and C. Type A is considered to be the original Chinese ancestral type. Type B is found in Asia, Europe and the US and has diverged from A with 2 mutations. Type C differs from type B at one site and is mostly confined to Europe and mostly absent from China.
More recently, researchers have alerted that a new strain, D614G, has become dominant in many countries. The D614G variant first came to our attention in early April, as we had observed a strikingly repetitive pattern. All over the world, even when local epidemics had many cases of the original form circulating, soon after the D614G variant was introduced into a region it became the prevalent form, wrote theoretical biologist at Los Alamos National Laboratory Bette Korber, in the journal Cell .
This mutation is present in roughly two third of all global strains, according to Associate Professor Denis Bauer, transformational bioinformatics team leader at CSIROs Australian e-Health Research Centre. The mutation that originated in the virus spike protein (not the RBD section) is thought to make it more contagious, but speculation that the virus is more virulent is extremely difficult to prove.
Scientists from the Department of Epidemiology of Microbial Diseases at the Yale School of Public Health led by Nathan D. Grubaugh published a paper in Cell titled Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear. The paper examines whether the strain is more transmissible, infectious, or deadly, but concludes that these data do not prove that G614 is more infectious or transmissible than viruses containing D614. They conclude there is no evidence that the virus strain leads to more severe disease.
The history of human populations and coronaviruses indicate a possible course for the current pandemic. For instance, the virus OC43 is responsible for the common cold, but a study by researchers from the University of Leuven in Belgium suggest it may have been responsible for a pandemic in 1889 that killed more than 1 million people internationally. They speculate that humans eventually developed immunity against the virus, making future infections more benign.
The course of this pandemic is on par with one of historys most severe health crisis in modern times. For humanity to develop herd immunity to SARS-CoV-2 would imply untold millions of deaths and incompletely understood chronic health morbidities. Yet, in the 21st century, where scientific knowledge is capable with confronting the threat, capitalism enchains humanitys ability to respond in kind.
11:49 AM 8/24/2020 - Portland police forced to prioritize protests unable to immediately respond to other 911 calls

Michael_Novakhov shared this story from The FBI News Review.

RT @thehill: Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l

Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l



Retweeted by mikenov on Tuesday, August 25th, 2020 9:14am


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RT @thehill: WeChat users sue Trump administration to block ban on Chinese app hill.cm/b8f2wKV pic.twitter.com/ViOf8fsyH2

WeChat users sue Trump administration to block ban on Chinese app hill.cm/b8f2wKV pic.twitter.com/ViOf8fsyH2



Retweeted by mikenov on Sunday, August 23rd, 2020 12:57pm


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11:47 AM 8/23/2020 - "A liar with 'no principles'" trumpinvestigations.blogspot.com/2020/08/1147-a pic.twitter.com/0rhaBiwoB1

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2:14 PM 8/23/2020 - WATCH: Graham shares newly declassified FBI docs showing 'clear' bias toward Trump - Michael Novakhov - SharedNewsLinks fbinewsreview.blogspot.com/2020/08/214-pm pic.twitter.com/smUZfBgbRu



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Saved Stories - 1. New York and Brooklyn 
Kremlin: Navalny poisoning accusations 'empty noise'

The Kremlin has rejected accusations of involvement in an alleged attack on Russian opposition leader Alexei Navalny who is in a coma in a German hospital.

Fierce storm surge feared as Laura bears down on Gulf Coast

Tropical Storm Laura has entered the warm waters of the Gulf of Mexico, gathering strength on a path to hit the U.S. coastline early Thursday as a major hurricane, capable of devastating damage.

Nationwide manhunt for suspects in three-state shooting spree ends with arrests of man, woman

A nationwide manhunt for the suspects involved in a series of shootings spanning three states has culminated in two arrests.





Brooklyns most and least expensive neighborhoods - The Real Deal

Brooklyns most and least expensive neighborhoods  The Real Deal
Crash on Brooklyn-bound Verrazzano-Narrows Bridge causes delays - SILive.com

Crash on Brooklyn-bound Verrazzano-Narrows Bridge causes delays  SILive.com
The Brooklyn News And Times - bklynnews.com bklynnews.com

The Brooklyn News And Times - bklynnews.com bklynnews.com

AP-NORC poll: Many in US shoring up finances amid downturn

A new poll from The Associated Press-NORC Center for Public Affairs Research finds 45% of Americans say they are setting aside more money than usual during the coronavirus pandemic.


Laura, now a hurricane, takes aim at U.S. Gulf Coast

Laura has become a hurricane shortly after moving over the warm waters of the Gulf of Mexico.


Japanese Prime Minister Shinzo Abe sparks health concerns with hospital visit as he becomes nations longest-serving leader

A second hospital visit in the span of a week has sparked concern for the health of Japanese Prime Minister Shinzo Abe, who just set the record for the countrys longest serving head of government.



Florida appeals judges ruling that blocks state order to reopen schools amid coronavirus pandemic

Florida officials have already filed an appeal against a judges Monday ruling that schools could not be forced to reopen for in-person learning, continuing a contentious battle between administrators and teachers.



Father says Black Wisconsin man shot by police is paralyzed

The father of a Black man who was shot, apparently in the back, by police in Kenosha, Wisconsin, says his son was left paralyzed from the waist down.


Reimagined Coney Island Mermaid Parade slated for this weekend

Sea monsters and fin folk can tune into a virtual livestream of Coney Island’s beloved Mermaid Parade this Saturday, Aug. 29, which will feature musical performances, dances, and marches, according to its organizers.
“You might see some familiar faces,” said Mark Alhadeff, a member of the arts organization Coney Island USA who helped host the event, now in its 38th year. “A lot of your favorites from the Mermaid Parade sent things in.”
The Mermaid Parade, which was postponed from its original June 20 date due to the coronavirus outbreak, will be held online to prevent the virus from spreading, Alhadeff said. A small group of participants will perform in an undisclosed, Coney Island location for a livestream that viewers can stream on Coney Island USA’s website, he said.
“Our MCs are here, some specials guests are here,” said Alhadeff, who emphasized that the in-person performance space will follow strict social-distancing guidelines. “It’s a very, very big space. It’s incredibly well ventilated.”
In addition to live dances and marches, the event will also feature pre-recorded performances by well-known musicians singing songs about Coney Island, such as Arlo Guthrie, the lead singer of the rock band Death Cab for Cutie, and the lead singer of the alternative rock band The Feelies.

Ben Gibbard, the lead singer for the hit rock band Death Cab for Cutie, submitted a video of him singing a song about Coney Island.Ben Gibbard
The show has received nearly 200 video submissions from potential participants so far, said Alhadeff, who added that some of his favorite footage features costumed revelers parading through their apartments by themselves.
“We’re hoping to have some people who literally parade,” he said. “People going back and forth across their apartments it makes me happy.”
The event’s hosts originally planned to partner with bars across the country to host disparate, live-streamed celebrations of the festival, but Coney Island USA decided to go completely virtual out of concern for viewers’ health, Alhadeff said.
“Because of what’s going on in the world, we killed the venue concept on the whole,” he said. “We are not officially sanctioning any venues.”

Parade organizers with Coney Island USA are working tirelessly to set up the venue where some performers will perform live for the virtual Mermaid Parade on Aug. 29.Norman Blake
Rather than taking the form of a parade or party, the reimagined event will imitate a 1970s charitable telethon, Alhadeff said. Viewers can make donations throughout the livestream on the organization’s website, which will go to Coney Island USA and other local non-profits including include the youth services program Salt and Sea Mission, the southern Brooklyn community organization Urban Neighborhood Services, and the Brooklyn arts organization BRIC, among others.
In the style of a telethon, the event’s hosts will give shoutouts and prizes to donors, impersonate the 1970s telethon performer Jerry Lewis, and count the donations as they roll in on a gigantic thermometer, Alhadeff said.
Participants may also enter the parade’s annual costume awards, known as the Mermies, which dole out trophies for the best mermaid and Neptune costumes, the best kids costume, the best sea creature, and the best music group, among other categories.
Despite the parade’s setbacks due to the coronavirus outbreak, Alhadeff said that the Aug. 29 event will capture the spirit of the fun-loving parade.
“It’s basically a big variety show with Jerry [Lewis] in between,” he said. “If you’ve been to the Mermaid Parade, it will probably feel familiar.”



Kremlin: Navalny poisoning accusations 'empty noise'

Michael_Novakhov shared this story from News 12 - Home.

The Kremlin has rejected accusations of involvement in an alleged attack on Russian opposition leader Alexei Navalny who is in a coma in a German hospital.


Kenosha delayed body cameras for years before Blake shooting

Officials in Kenosha, Wisconsin, have put off implementing body cameras for police officers, even though leaders unanimously endorsed them more than three years ago as a way to increase police accountability and collect evidence at scenes of domestic violence.


6:48 AM 8/25/2020 - New Wave of COVID-19 Cases Hits Brooklyn Communities



6:48 AM 8/25/2020 - New Wave of COVID-19 Cases Hits Brooklyn Communities




Michael Novakhov - SharedNewsLinks℠ | In Brief | 
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Michael Novakhov - SharedNewsLinks 
Kenosha delayed body cameras for years before Blake shooting
The Latest: UN says tourism impact of pandemic devastating
Trump convention blurs official business and politics
WHAT TO WATCH: Melania, Pompeo and Trump at GOP convention
Republican convention showcases rising stars, dark warnings
Scotland's handling of virus boosts support for independence
Germany economy's 2nd-quarter decline revised to below 10%
Global stocks rise, spurred by hopes for COVID treatment
Police use tear gas as protesters loot and burn buildings in Kenosha after Jacob Blakes shooting - Washington Post
New Wave of COVID-19 Cases Hits Brooklyn Communities
New Wave of COVID-19 Cases Hits Brooklyn Communities
NPR News: 08-25-2020 6AM ET
RT @thehill: Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW
5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo
5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov
RT @thehill: Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l
Google Alert - Covid-19: Governor Cuomo Announces New Record-Low COVID-19 Test Positivity Rate
The origins and evolution of the SARS-CoV-2 virus
11:49 AM 8/24/2020 - Portland police forced to prioritize protests unable to immediately respond to other 911 calls
Freedom FM Radio Network: FOX News: Portland police forced to prioritize protests unable to immediately respond to other 911 calls
New York Daily News: 13 killed in stampede after trying to run from cops at illegal nightclub party in Peru: officials
Top stories Google News: Disability, Work and Coronavirus: What Happens Now? The New York Times
7:40 AM 8/24/2020 - Saved, Shared Stories, Tweets
Steve Bannons indictment marks the end of a political era - Tweets by @mikenov Sat, 22 Aug 2020 06:40:37
6:07 AM 8/24/2020 - Report: Israel pushed NSO spyware to Gulf states to help track dissidents. Government reported to mediate deals worth hundreds of millions with Bahrain, Oman, Saudi Arabia, UAE
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Michael Novakhov - SharedNewsLinks 
Kenosha delayed body cameras for years before Blake shooting

Michael_Novakhov shared this story from News 12 - Home.

Officials in Kenosha, Wisconsin, have put off implementing body cameras for police officers, even though leaders unanimously endorsed them more than three years ago as a way to increase police accountability and collect evidence at scenes of domestic violence.

The Latest: UN says tourism impact of pandemic devastating

Michael_Novakhov shared this story from News 12 - Home.

The United Nations chief says the tourist industry has been devastated by the COVID-19 pandemic, with $320 billion lost in exports in the first five months of the year and over 120 million jobs at risk.

Trump convention blurs official business and politics

Michael_Novakhov shared this story from News 12 - Home.

Plenty of presidents have walked right up to the line separating official business from politics or even stepped over it.

WHAT TO WATCH: Melania, Pompeo and Trump at GOP convention

Michael_Novakhov shared this story from News 12 - Home.

Tuesdays program at the Republican National Convention is likely to wade into familiar waters, with a lineup expected to speak on divisive issues like abortion and cancel culture, while lambasting Democratic rival Joe Biden and the Democrats' progressive wing.

Republican convention showcases rising stars, dark warnings

Michael_Novakhov shared this story from News 12 - Home.

Republicans opened Monday nights prime-time convention with dark warnings about Americas future if President Donald Trump doesnt win a second term.

Scotland's handling of virus boosts support for independence

Michael_Novakhov shared this story from News 12 - Home.

Scottish leader Nicola Sturgeon has won praise for her handling of the coronavirus pandemic, her calm and sober response to the crisis standing in contrast to the sometimes-chaotic approach of U.K. Prime Minister Boris Johnson.

Germany economy's 2nd-quarter decline revised to below 10%

Michael_Novakhov shared this story from News 12 - Home.

Germany's official statistics agency says the country's economy, Europes biggest, shrank slightly less in the second quarter than originally estimated.

Global stocks rise, spurred by hopes for COVID treatment

Michael_Novakhov shared this story from News 12 - Home.

Asian shares are mostly higher as investors hang onto hopes the coronavirus pandemic may come under control with treatments being developed.

Police use tear gas as protesters loot and burn buildings in Kenosha after Jacob Blakes shooting - Washington Post

Michael_Novakhov shared this story from "Madison Brooklyn" - Google News.

Police use tear gas as protesters loot and burn buildings in Kenosha after Jacob Blakes shooting  Washington Post
New Wave of COVID-19 Cases Hits Brooklyn Communities

Michael_Novakhov shared this story from Google Alert - Coronavirus in brooklyn.

While the Boro Park Jewish community was hit hard early on by the coronavirus, and it seemed that the disease then seemed to have nearly ...
New Wave of COVID-19 Cases Hits Brooklyn Communities

Michael_Novakhov shared this story from Hamodia.

NEW YORK -
While the Boro Park Jewish community was hit hard early on by the coronavirus, and it seemed that the disease then seemed to have nearly disappeared, in recent days it turns out that there are dozens of cases of patients who became infected with the virus again. Hundreds of people were niftar in March and April. Currently, there are a few patients in the hospital and even some in the ICU.
On Monday researchers in Hong Kong reported that a man there had been reinfected with the coronavirus four and a half months after being declared recovered.
But a true reinfection requires genetic testing of the virus in both the first and second infection to see whether the two instances of the virus differ slightly.
The gabbaim of the Bobov kehillah in Boro Park on Monday issued a warning that new cases of coronavirus are cropping up.
They said that people at risk should be careful not to be in places where social distancing is not possible. At risk is defined as anyone over the age 60, if he or she has underlying conditions, or doesnt have antibodies.
Williamsburg Hatzolah told their members that they have also received reports that some people in the community have tested positive for coronavirus. They noted that they are monitoring the situation closely.
We ask all members to make sure to wear PPE on every single call for the safety of the members and the safety of our community, they request, and whenever you are dispatched to a suspected Covid call or a confirmed Covid call to contact W-80 so we can keep track and take the appropriate steps.
NPR News: 08-25-2020 6AM ET

Michael_Novakhov shared this story from NPR News Now.

NPR News: 08-25-2020 6AM ET



Download audio: https://play.podtrac.com/npr-500005/edge1.pod.npr.org/anon.npr-mp3/npr/newscasts/2020/08/25/newscast060746.mp3?awCollectionId=500005&awEpisodeId=905763932&orgId=1&d=300&p=500005&story=905763932&t=podcast&e=905763932&size=4500000&ft=pod&f=500005
RT @thehill: Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW

Michael_Novakhov shared this story from mikenov on Twitter.

Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW



Retweeted by mikenov on Tuesday, August 25th, 2020 9:39am


164 likes, 60 retweets
5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo

Michael_Novakhov shared this story from mikenov on Twitter.

5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo



5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov

Michael_Novakhov shared this story from The FBI News Review.

New Wave of COVID-19 Cases Hits Brooklyn Communities

While the Boro Park Jewish community was hit hard early on by the coronavirus, and it seemed that the disease then seemed to have nearly ...
German FM heads to Greece, Turkey as regional tension mounts

Germany's foreign minister is heading to Greece and Turkey Tuesday in an effort to ease increasing tension between the two neighbors that are at loggerheads over prospecting rights in the eastern Mediterranean.






RT @thehill: Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW

Trump approval on handling pandemic drops to 31 percent: poll hill.cm/oiQyBPY pic.twitter.com/yaM0adkRCW



Retweeted by mikenov on Tuesday, August 25th, 2020 9:39am


164 likes, 60 retweets
5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo

5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov fbinewsreview.blogspot.com/2020/08/547-am pic.twitter.com/r1Y3uxD3Eo



5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov

 


5:47 AM 8/25/2020 - News Reviews - The News and Times - Blogs By Michael Novakhov




Michael Novakhov - SharedNewsLinks℠ | In Brief | 
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Michael Novakhov - SharedNewsLinks 
RT @thehill: Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l
Google Alert - Covid-19: Governor Cuomo Announces New Record-Low COVID-19 Test Positivity Rate
The origins and evolution of the SARS-CoV-2 virus
11:49 AM 8/24/2020 - Portland police forced to prioritize protests unable to immediately respond to other 911 calls
Freedom FM Radio Network: FOX News: Portland police forced to prioritize protests unable to immediately respond to other 911 calls
New York Daily News: 13 killed in stampede after trying to run from cops at illegal nightclub party in Peru: officials
Top stories Google News: Disability, Work and Coronavirus: What Happens Now? The New York Times
7:40 AM 8/24/2020 - Saved, Shared Stories, Tweets
Steve Bannons indictment marks the end of a political era - Tweets by @mikenov Sat, 22 Aug 2020 06:40:37
6:07 AM 8/24/2020 - Report: Israel pushed NSO spyware to Gulf states to help track dissidents. Government reported to mediate deals worth hundreds of millions with Bahrain, Oman, Saudi Arabia, UAE
7:04 AM 8/24/2020 - Tweets by @mikenov: News - NSO Group and FBI
mikenov on Twitter: RT @haaretzcom: Trump and Netanyahu are using textbook gaslighting tactics. But there are ways to resist their psychological manipulation h
1. World from Michael_Novakhov (27 sites): FOX News: AI pilot beats human in clean sweep of virtual F-16 dogfights, human fails to register a single hit
2:14 PM 8/23/2020 - WATCH: Graham shares newly declassified FBI docs showing 'clear' bias toward Trump - Michael Novakhov - SharedNewsLinks
Trump News TV from Michael_Novakhov (15 sites): FoxNewsChannel's YouTube Videos: WATCH: Graham shares newly declassified FBI docs showing 'clear' bias toward Trump
"fbi and trump" - Google News: Transcript: Former FBI Director James Comey on "Face the Nation," August 23, 2020 - CBS News
"fbi criticism" - Google News: Comey: Bannon in 'a world of trouble' | TheHill - The Hill
Trump News TV from Michael_Novakhov (15 sites): CNN's YouTube Videos: Covid-19 case counts trending up in 9 states
mikenov on Twitter: 11:47 AM 8/23/2020 - "A liar with 'no principles'" trumpinvestigations.blogspot.com/2020/08/1147-a pic.twitter.com/0rhaBiwoB1
"house judiciary committee" - Google News: How a Senate panel went beyond Mueller in documenting Trump campaign contacts with Russia - KTEN
Trump News TV from Michael_Novakhov (15 sites): CNN's YouTube Videos: Trump's sister criticizes her brother in secretly recorded audio
Top stories - Google News: Coronavirus hasn't stopped groups from gathering, but it has led to grim consequences - CNN
The National Interest: The Classic Remington Model 1100 Shotgun: All-Around Excellence Through the Decades
Stars and Stripes: High winds could fan already-enormous California wildfires
"Russia" - Google News: How a Senate panel went beyond Mueller in documenting Trump campaign contacts with Russia - CNN
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Michael Novakhov - SharedNewsLinks 
RT @thehill: Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l

Michael_Novakhov shared this story from mikenov on Twitter.

Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l



Retweeted by mikenov on Tuesday, August 25th, 2020 9:14am


162 likes, 48 retweets
Google Alert - Covid-19: Governor Cuomo Announces New Record-Low COVID-19 Test Positivity Rate

Michael_Novakhov shared this story from Disease X-19 General Issues from Michael_Novakhov (4 sites).

17th Straight Day with Positivity Rate Below 1 Percent; 0.66 Percent of Yesterday's COVID-19 Tests were Positive. Port Authority of New York and New ...

 Google Alert - Covid-19
The origins and evolution of the SARS-CoV-2 virus

Michael_Novakhov shared this story from World Socialist Web Site (en).

 

The origins and evolution of the SARS-CoV-2 virus

By Frank Gaglioti
24 August 2020
The SARS-CoV-2 virus that causes the disease COVID-19 is nimbly and stealthily racing through community after community devastating the worlds population. Over 23 million people have contracted the virus worldwide and 810,000 have died. It is critical to review the evolutionary history of this particular virus to provide necessary insights into how the pandemic can be brought under control.
Researchers worldwide are working arduously to trace the virus globally by studying samples obtained from various nations looking for subtle mutations that it undergoes as it infects, replicates and multiplies, providing them clues to the source and route of spread.
COVID-19 is caused by a type of coronavirus known as SARS-CoV-2, named for its similarity to the coronavirus that caused SARS. The virus is called a coronavirus because it is covered by club-like structures that give the virus a similar look to the suns corona in electron micrographs.
The SARS-CoV-2 virus is part of a family of organisms that are known to infect mammals and birds. The Coronaviridae family are made up of a positive-sense single-stranded RNA completely enveloped in a complex protein and bilipid shell. These viruses are relatively large, consisting of 26 to 32 kilobase pairs. RNA or ribonucleic acid is a nucleic acid that is essential for all reproductive processes and like DNA.
The first known scientific encounter with this family of virus is thought to be when veterinarians puzzled over bronchial infections afflicting cats, pigs, and chickens in the early 20th century.
Study of disease afflicting and damaging tobacco crops in the late 19th century led some thoughtful scientists like Dimitri Ivanovsky to conjecture the existence of non-bacterial infectious agents causing the tobacco mosaic disease. It would take another 50 years to capture the first images of the Tobacco Mosaic Virus. The invention of the electron microscope in 1931 enabled scientists to observe viruses more closely, allowing a more extensive and direct study of these micro-organisms. Virology as a field began to flourish.
Human coronaviruses were first identified in the 1960s. Seven species of coronavirus are known to afflict humans. Four result in relatively mild upper respiratory tract conditions, including the virus 229E that causes the common cold, along with NL63, OC43 and HKU1.
The other three strains, SARS, MERS, and SARS-CoV-2, are far more virulent. All these viruses were new to human populations when they first arose in the 21st century. A feature of SARS, MERS and COVID-19 is that they had a zoonotic origin, that is they originated in animal populations and then jumped into humans. The SARS outbreak in 2002, with a case fatality rate of 11 percent, showed the world the deadly potential of coronaviruses, but this was a warning that was mostly ignored. There had only been 8,422 cases and since 2004 no SARS-CoV has been reported worldwide. One advantage for public health responses to SARS was that it had an incubation period of 4 to 6 days and patients presented with symptoms prior to becoming infectious.
In their extensive investigations, the World Health Organisation (WHO) concluded that the SARS virus originated in bat populations, but the exact species remains unknown. Work commenced on the development of a SARS vaccine with testing on animals. The vaccine resulted in protective immunity but produced an immune mediated hypersensitivity as an adverse effect. The SARS threat, for unknown reasons, expired after six months though limited outbreaks did occur later.
With the threat of a pandemic having ended after six months, so did any interest in funding a vaccine, as pharmaceutical companies saw no profit in funding or exploring such research. The co-director of the Center for Vaccine Development at Texas Childrens Hospital and dean of the National School of Tropical Medicine at the Baylor College of Medicine in Houston, Dr. Peter Hotez, had been attempting to develop a SARS vaccine in 2016 but couldnt get funding for his work. We tried like heck to see if we could get investors or grants to move this into the clinic ... But we just could not generate much interest, he said.
We could have had this ready to go and been testing the vaccines efficacy at the start of this new outbreak in China (COVID-19) There is a problem with the ecosystem in vaccine development, and weve got to fix this, Hotez said.
The genomic sequence of the SARS virus was published in August 2003 by Chinese scientists in Beijing. In actuality, when the cause of the pneumonia-like illness was first identified in Wuhan, some believed this was a new outbreak of the SARS virus. SARS-CoV-2 and SARS share a genomic sequence that is approximately an 80 percent match.
Middle East Respiratory Syndrome, or MERS, emerged in Saudi Arabia in 2012 and had a zoonotic origin in bats and was spread to humans through contact with dromedary camels. The virus produced symptoms similar to SARS but it had a low infectivity though highly lethal. Of the reported 2,500 cases, 35 percent died from the disease.
With limited capacity to spread from human to human, it was mainly passed through contact with infected people in hospitals. In the main it was concentrated in the Arabian Peninsula, although there were further outbreaks in South Korea in 2015 and Saudi Arabia in 2018. It continues to smoulder in the Middle East.
When the SARS CoV-2 virus emerged in late 2019, the world was totally unprepared. Health systems internationally had been systematically run down and were ill-equipped to respond. The warnings from WHO of the dangerous potential of the virus were largely ignored or belittled. The murderous government policies that dominated have been described as malign neglect or herd immunity.
SARS CoV-2 arose in Wuhan in December 2019. The virus is thought to have originated from bats and to have transferred to humans through an intermediary species. The exact origins of the virus may never be known. It is quite possible we wont find it (the species). In fact, it would be exceptionally lucky if we land on something, a geneticist from University College London, Lucy van Dorp, told Nature .
Back in 2013, the Wuhan Institute of Virology had investigated the coronavirus genome from the horseshoe bat ( Rhinolophus affinis ). The viruses named RATG13 and SARS-CoV-2 were found to be 96 percent genetically similar. There are, however, subtle molecular changes that continue to be investigated that contribute to selection pressures that drive the virulence, pathogenicity, and immunogenic qualities of the virus.
In their detailed analysis of the origin of the SARS-CoV-2 virus, Andersen et al., 2020, offered three possible explanations: 1) natural selection in an animal host before jumping into humans, 2) natural selection in humans after the virus transferred into human hosts, and 3) the product of artificial manipulation, which has been refuted by several virologists. According to Van Dorp, the 4% difference between the genomes of SARS-CoV-2 and RATG13 still represents some 50 years since they last shared a common ancestor.
It was thought that pangolins ( Manis javanica ), a scaly ant-eating mammal, may be the intermediate host between bats and humans, but genetic studies indicate that as unlikely. However, some scientists think that because coronavirus-like SARS-CoV-2 cases have been found in pangolins, that species cannot be ruled out as the intermediary source.
Scientists are currently examining species of animals that were kept and sold in the live markets in Wuhan where bats may have been in the buildings roof near animals and humans. Presently a team of experts from the WHO are working with their Chinese counterparts to answer this pressing question.
The opportunities for these viruses to spill over across a very active wildlife-livestock-human interface is clear and obvious, the president of the EcoHealth Alliance in New York City, Peter Daszak, told Nature. The complex evolutionary history of SARS-CoV-2 disproves President Donald Trumps ignorant claims (which have a political purpose) that the virus came out of a Chinese laboratory. Whether they [China] made a mistake, or whether it started off as a mistake and then they made another one, or did somebody do something on purpose? Trump said.
In a recent paper published in Nature Microbiology Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the covid-19 pandemic, led by Maciej F Boni from the Center for Infectious Disease Dynamics at Pennsylvania State Universityfound that the lineage of SARS-CoV-2 had been circulating in bat populations for decades. If these viruses have been around for decades that means that theyve had lots of opportunity to find new host species, including humans, said Professor David Robertson from the University of Glasgow.
Scientists have carefully examined the Receptor Binding Domain (RBD) of the genetic sequence that codes for the spike protein, the necessary structure on the virus exterior shell that is used to bind and penetrate the human cell. The spike protein has been compared to a grappling hook that grips the host cell, then creates a cleavage site that enables the opening and penetration into the host cell.
This means that the SARS-CoV-2 spike proteins had evolved to target a feature of human cells known as angiotensin converting enzyme 2 receptor (ACE2) which are well known to assist in regulating blood pressure.
Andersen et al ., remark that the RBD is the critical component of the spike protein that allows it to bind to ACE2 receptors. SARS-CoV-2 appears to bind with great affinity to the human ACE2 receptors, but computational analysis predicted that the interaction is not ideal. According to the New York Times, the authors indicate that the high-affinity bindings of the virus spike protein to human ACE2 is most likely a by-product of natural selection that has permitted another optimal binding solution to arise. They then conclude that this is strong evidence that SARS-CoV-2 is not a product of genetic reconstruction or tampering.
These two features of the virus, the mutations in the RBD portion of the spike protein and its distinct backbone, rule out laboratory manipulation as a potential origin for SARS-CoV-2, wrote Kristian Andersen, associate professor of immunology and microbiology at Scripps Research, and co-leader of the study.
With SARS-CoV-2 virus proliferating around the world, the opportunity arises for further mutations and the emergence of new strains of the virus. This can mean that new virus strains may develop in the future not treatable by possible vaccines that were originally made to treat older strains.
According to Assistant Teaching Professor of Computer Science and Technology Niema Moshiri, COVID-19s mutation rate is lower than seasonal influenza. The SARS-CoV-2 genome has a limited repair function that edits out most mutations. This has meant the virus has remained relatively uniform.
What we are finding is that the SARS-CoV-2 virus appears to be mutating more slowly than the seasonal flu which may allow scientists to develop a vaccine, Moshiri wrote on LiveScience. Despite this, variations do occur, and virologists are constantly looking at the variants to determine if a more virulent strain may be emerging or if the virus is losing its potency.
Scientists are collecting virus sequences and storing them in a globally available database. This is used to determine the rate of mutation and where in the virus genome mutations are occurring. Such mutations can affect the virulence and how effectively the virus can infect human host cells. The existence of different viral strains can be used to trace outbreaks.
Analysis of the SARS-CoV-2 virus from different countries has shown that the virus has undergone several predicted but insignificant mutations already. Scientists led by Peter Forster, along with researchers based in the UK and Germany, traced 160 COVID-19 genomes from China, Europe, and the US. They identified three strains of the virus called A, B and C. Type A is considered to be the original Chinese ancestral type. Type B is found in Asia, Europe and the US and has diverged from A with 2 mutations. Type C differs from type B at one site and is mostly confined to Europe and mostly absent from China.
More recently, researchers have alerted that a new strain, D614G, has become dominant in many countries. The D614G variant first came to our attention in early April, as we had observed a strikingly repetitive pattern. All over the world, even when local epidemics had many cases of the original form circulating, soon after the D614G variant was introduced into a region it became the prevalent form, wrote theoretical biologist at Los Alamos National Laboratory Bette Korber, in the journal Cell .
This mutation is present in roughly two third of all global strains, according to Associate Professor Denis Bauer, transformational bioinformatics team leader at CSIROs Australian e-Health Research Centre. The mutation that originated in the virus spike protein (not the RBD section) is thought to make it more contagious, but speculation that the virus is more virulent is extremely difficult to prove.
Scientists from the Department of Epidemiology of Microbial Diseases at the Yale School of Public Health led by Nathan D. Grubaugh published a paper in Cell titled Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear. The paper examines whether the strain is more transmissible, infectious, or deadly, but concludes that these data do not prove that G614 is more infectious or transmissible than viruses containing D614. They conclude there is no evidence that the virus strain leads to more severe disease.
The history of human populations and coronaviruses indicate a possible course for the current pandemic. For instance, the virus OC43 is responsible for the common cold, but a study by researchers from the University of Leuven in Belgium suggest it may have been responsible for a pandemic in 1889 that killed more than 1 million people internationally. They speculate that humans eventually developed immunity against the virus, making future infections more benign.
The course of this pandemic is on par with one of historys most severe health crisis in modern times. For humanity to develop herd immunity to SARS-CoV-2 would imply untold millions of deaths and incompletely understood chronic health morbidities. Yet, in the 21st century, where scientific knowledge is capable with confronting the threat, capitalism enchains humanitys ability to respond in kind.
11:49 AM 8/24/2020 - Portland police forced to prioritize protests unable to immediately respond to other 911 calls

Michael_Novakhov shared this story from The FBI News Review.

RT @thehill: Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l

Biden holds 52-point lead over Trump among college students: poll hill.cm/3vR0DW7 pic.twitter.com/bVBS8LOU5l



Retweeted by mikenov on Tuesday, August 25th, 2020 9:14am


162 likes, 48 retweets
RT @thehill: WeChat users sue Trump administration to block ban on Chinese app hill.cm/b8f2wKV pic.twitter.com/ViOf8fsyH2

WeChat users sue Trump administration to block ban on Chinese app hill.cm/b8f2wKV pic.twitter.com/ViOf8fsyH2



Retweeted by mikenov on Sunday, August 23rd, 2020 12:57pm


53 likes, 21 retweets


38 likes, 15 retweets
11:47 AM 8/23/2020 - "A liar with 'no principles'" trumpinvestigations.blogspot.com/2020/08/1147-a pic.twitter.com/0rhaBiwoB1

2:14 PM 8/23/2020 - WATCH: Graham shares newly declassified FBI docs showing 'clear' bias toward Trump - Michael Novakhov - SharedNewsLinks fbinewsreview.blogspot.com/2020/08/214-pm pic.twitter.com/smUZfBgbRu

2:14 PM 8/23/2020 - WATCH: Graham shares newly declassified FBI docs showing 'clear' bias toward Trump - Michael Novakhov - SharedNewsLinks fbinewsreview.blogspot.com/2020/08/214-pm pic.twitter.com/smUZfBgbRu



6:07 AM 8/24/2020 - Report: Israel pushed NSO spyware to Gulf states to help track dissidents. Government reported to mediate deals worth hundreds of millions with Bahrain, Oman, Saudi Arabia, UAE fbinewsreview.blogspot.com/2020/08/607-am pic.twitter.com/QmPzWVVwfW

6:07 AM 8/24/2020 - Report: Israel pushed NSO spyware to Gulf states to help track dissidents. Government reported to mediate deals worth hundreds of millions with Bahrain, Oman, Saudi Arabia, UAE fbinewsreview.blogspot.com/2020/08/607-am pic.twitter.com/QmPzWVVwfW



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